|
August 1, 2010 -- Houston, Texas:
Bi-annual report from Steven A. Curley, MD, lead investigator of the Kanzius Non-invasive RF Cancer Treatment program at M. D. Anderson Cancer Center
Laboratory Staff and Equipment
Our post-doc from the University of Arizona, Dr. Evan Glazer, completed his work in June 2010 and has returned to Arizona. He was incredibly productive during his two years in the lab and published a number of important papers. While he is certainly missed, he has already been replaced by another post-doc from the University of Arizona, Dr. Mustafa Raoof. We have also added another molecular biologist who is an expert in animal tumor models and targeting of drugs and particles to cancer cells, Dr. Nadya Koshkina. We are currently looking to add yet another post-doc who is an expert in mathematical modeling and simulation to better understand the barriers to delivery of the targeted gold nanoparticles to reach the cancer cells. This work will be critical in demonstrating modeling and experimental confirmation of successful delivery of the gold nanoparticles to malignant tumors in humans. We also hope to have one last addition to the group in the next month, an expert in bioengineering and nanoparticle fabrication. Assuming we are successful in recruiting this bioengineer soon, this will bring the number of people working on the project in the Kanzius Labs to 16 people.
Publications
- Published July 2010 in Cancer - Radiofrequency field-induced thermal cytotoxicity in cancer cells treated with fluorescent nanoparticles. This paper shows that nanoparticles kill only cancer cells they are targeted to, and shows that nanoparticles can be used both to diagnose cancer using lasers or CT scans and then killed with the Kanzius RF device.
 DOWNLOAD HERE »
- Published August 2010 in Surgery - Bioengineered arginase I increases caspase-3 expression of hepatocellular and pancreatic carcinoma cells despite induction of arginosuccinate synthetase. This paper shows increased sensitization of cancer cells when deprived of the nutrient arginine. This makes the cells more susceptible to heat damage. DOWNLOAD HERE »
- Published August 2010 in Surgery - Pancreatic carcinoma cells are susceptible to non-invasive radiofrequency fields after treatment with targeted gold nanoparticles. Further work showing that human pancreatic cancer cells can be killed with targeted gold nanoparticles and the Kanzius RF field. DOWNLOAD HERE »
- Submitted 2010 - A paper proving that the gold nanoparticles by themselves are not toxic or harmful to rabbits.
- Submitted 2010 - A big one, this shows targeted in animals with pancreatic cancer and control of the pancreatic cancers without harmful effects to the animals.
|
